Is topiramate effective for migraines? Patients taking topiramate daily were more likely to report a 50% or more reduction in headache frequency compared with patients taking placebo (relative risk = 2.02; 95% CI, 1.57 to 2.60). The number needed to treat for a 50% reduction in migraine headaches with topiramate vs. placebo was 4 (95% CI, 3 to 6).
