Which antidepressant is best for migraine? Amitriptyline is the best-studied and most common antidepressant used for migraine prevention. It has a long history of use for migraine. For some people, amitriptyline may work well but cause intolerable side effects. In this case, nortriptyline may be an alternative.
Is lexapro used for migraines? SSRIs are the most popular drugs for the treatment of anxiety and depression, but they are ineffective for the treatment of pain, migraines, and other headaches. These drugs include Prozac (fluoxetine), Paxil (paroxetine), Lexapro (escitalopram), Zoloft (sertraline) and other.
Do SSRI make migraines worse? One would think that SSRIs, which look to increase serotonin, would help migraine, but it is not as simple as “high serotonin is good and low serotonin is bad,” explained Dr. Charles. These drugs react differently in each patient, and may deliver the opposite effect intended, leading to migraine.
What medication is used for migraines and anxiety? Amitriptiline can be used both in mood disorders and migraine prevention. Flunarizine and beta-blockers may help if anxiety is present. Pregabalin has demonstrated efficacy in anxiety disorders and fibromyalgia.