Which antidepressant is best for migraines? Amitriptyline is the best-studied and most common antidepressant used for migraine prevention. It has a long history of use for migraine. For some people, amitriptyline may work well but cause intolerable side effects. In this case, nortriptyline may be an alternative.
Why do antidepressants help migraines? How do tricyclic antidepressants help prevent migraine? During a migraine attack, doctors believe that your serotonin levels plummet. Tricyclic antidepressants help prevent attacks from happening as frequently by maintaining a healthy serotonin level.
Does Zoloft cause migraines? It’s common to experience headaches, nausea, and fatigue during your first week on Zoloft. These side effects often get better over the first week or two.
What is the most prescribed drug for migraines? The most commonly prescribed class of drugs for migraine are the triptans. These are all meant to be taken on an as-needed basis, at the first sign of headache, and they include Sumatriptan (Imitrex); Zolmitriptan (Zomig); Rizatriptan (Maxalt); and Eletriptan (Relpax).