Why are opioids not used for migraines? Opioids are pro-nociceptive, prevent reversal of migraine central sensitization, and interfere with triptan effectiveness. Opioids precipitate bad clinical outcomes, especially transformation to daily headache. They cause disease progression, comorbidity, and excessive health care consumption.
Can you get opioids for migraines? To treat migraines, you may get a prescription for an opioid (narcotic) or a barbiturate (sedative) called butalbital. These are pain medicines.
Do opioids worsen headaches? Discussion: Although most acute headache treatments have been alleged to cause MOH, here we conclude from the literature that opioids are a particularly problematic drug class consistently associated with worsening headache.
Can oxycodone make a migraine worse? In addition to being addictive, two opioid medications — oxycodone and hydrocodone can also cause these rebound headaches. They are so powerful that just taking them once a week can cause your migraine to get worse in frequency and severity.