What is the ER migraine cocktail? A migraine cocktail administered in the ER may contain medications like nonsteroidal antiinflammatory drugs (NSAIDs), magnesium, triptans, and IV fluids. It may contain other medications as well, as there is a range of possible medications that can be administered in the ER for severe migraine.
How much Reglan should I take for migraines? The standard dose of metoclopramide for treatment of migraine is 10mg. Limited clinical data suggest that 20mg of intravenous metoclopramide is more efficacious than 10mg [11–13]. One study reported excellent anti-migraine efficacy with doses of metoclopramide up to 60mg, administered over 45 minutes.
Why does metoclopramide work for migraines? Metoclopramide is a non-phenothiazine central dopamine antagonist and a peripheral muscarinic agonist. It increases gastric emptying and is anti-emetic at the chemoreceptor trigger zone. It is postulated that metoclopramide acts in migraine by anti-emetic effects combined with central anti-dopamine effects.
What are the side effects of taking Reglan? Drowsiness, dizziness, tiredness, trouble sleeping, agitation, headache, and diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.