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How long does it take for venlafaxine to work for migraines?

How long does it take for venlafaxine to work for migraines? Although Effexor starts working as soon as it’s absorbed by your body, it typically takes several weeks to produce any noticeable changes in your mood, feelings and thoughts. You may experience some improvement in your appetite, sleep patterns and energy level in the first one to two weeks of using Effexor.