Can antipsychotics help migraines? Antipsychotic drugs. Antipsychotic drugs often are very effective for acute migraine, but of course they have significant side effects. Of the lot, haldol (haloperidol) is probably the most useful as a last-resort abortive medication.
Does Haldol cause headaches? Dizziness, lightheadedness, drowsiness, difficulty urinating, sleep disturbances, headache, and anxiety may occur. If these effects last or get worse, notify your doctor or pharmacist promptly. Dizziness and lightheadedness can increase the risk of falling.
What is the ER migraine cocktail? A migraine cocktail administered in the ER may contain medications like nonsteroidal antiinflammatory drugs (NSAIDs), magnesium, triptans, and IV fluids. It may contain other medications as well, as there is a range of possible medications that can be administered in the ER for severe migraine.
Why do antipsychotics help migraines? Antipsychotic treatment of migraines is supported by the theory that dopaminergic hyperactivity leads to migraine headaches (Table 1). Antipsychotics have been used off-label in migraine patients who do not tolerate triptans or have status migrainosus—intense, debilitating migraine lasting >72 hours.