How does Reglan work for migraines? Many drugs have been used for the treatment of acute migraine attacks; the antidopaminergic drugs used are metoclopramide and prochlorperazine. Both of these drugs antagonize the dopamine D2 receptor, also used to treat nausea and vomiting seen in acute migraines.
What is the ER migraine cocktail? A migraine cocktail administered in the ER may contain medications like nonsteroidal antiinflammatory drugs (NSAIDs), magnesium, triptans, and IV fluids. It may contain other medications as well, as there is a range of possible medications that can be administered in the ER for severe migraine.
How much Reglan should I take for migraines? The standard dose of metoclopramide for treatment of migraine is 10mg. Limited clinical data suggest that 20mg of intravenous metoclopramide is more efficacious than 10mg [11–13]. One study reported excellent anti-migraine efficacy with doses of metoclopramide up to 60mg, administered over 45 minutes.
What medications does the ER give for migraines? If you have an intractable migraine, or status migrainosus: Your ER doctor may give you a drug called dihydroergotamine (DHE-45) as an injection or through an IV, along with metoclopramide. They may also give you valproate in an IV. You may need to check into the hospital for a few days of these treatments.